Nandrolone Side Effects: Common, Severe, Long Term

Here you will find quality products that are both legal to obtain and without a prescription. Of course you may also find you’re buying from a direct scammer, someone that takes your money and provides no product. However, there are plenty of quality suppliers and you’ll find it’s also one of the most affordable steroids on the market.

This compound is converted into nandrolone analogously to the use of DHEA as a prohormone of testosterone (Wiki). It is sold as an over-the-counter supplement from certain online vendors, similarly to DHEA. 19-Nor-DHEA may be a more suitable option for transfeminine people due to the lower doses needed and less suitable for transmasculine people due to the much higher doses required. Nandrolone is an agonist of the androgen receptor (AR) similarly to testosterone. It shows higher affinity for the AR than does testosterone and has almost no binding affinity for sex hormone-binding globulin (SHBG) however. For these reasons, nandrolone has about 2.5- to 5-fold higher potency than testosterone in rats on measures of general AR agonistic strength, such as stimulation of muscle growth (Sundaram et al., 1995; Tóth & http://explicitclick.com/2024/12/igf1-lr3-1mg-peptide-sciences-7/ Zakár, 1986; Wiki; Winters, 1976).

Hassager and colleagues concluded that anabolic steroids stimulate type III collagen synthesis, which affects muscular tissues as well as bone tissues 111. ND has important effects on the hypothalamic—pituitary—adrenal Axis (HPAA) and on lipid metabolism. In a study by Gårevik et al., cholesterol level, steroid synthesizing enzymes in the adrenal gland (HMGCR) mRNA and Apo-lipoprotein B (ApoB) appeared to increase after a single dose of ND in humans, and this effect was persistent after 14 days 47.

Individuals with 5α-reductase type 2 deficiency undergo masculinization of the genitals at puberty such that a small and near-functional penis develops (Peterson et al., 1977; Marks, 2004; Hiort, 2013; Photos). This is so striking that males with 5α-reductase type 2 deficiency in the Dominican Republic are referred to as “guevedoces”, which is said to literally mean “penis at 12”. We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above.

Chemistry of Nandrolone

There are case reports of severe and complete masculinization of the voice in women treated with excessive doses of nandrolone (Damsté, 1964; Brodnitz, 1971; Baker, 1999). Voice changes have also been seen with nandrolone derivatives like normethandrone (Feldman et al., 1960). The dosage of nandrolone for use in androgen replacement therapy in women and men hasn’t been established. Hence, we don’t completely know what the appropriate dose is for use in transfeminine and transmasculine hormone therapy. Another potential means of delivering nandrolone is via an orally active nandrolone androgen prohormone like 19-nordehydroepiandrosterone (19-nor-DHEA).

Pubchem.ncbi.nlm.nih.gov. 2021. Nandrolone. online Available at:

As an example, transmasculine people taking full male androgen replacement doses should probably expect no less oily skin or acne with nandrolone than with testosterone. Conversely, transfeminine people taking nandrolone at doses equivalent to the effect of testosterone levels in the normal female range may experience less or possibly no oily skin or acne with nandrolone compared to use of testosterone instead. This is due to the equivalent testosterone levels being far closer to the biological threshold for manifestation of such effects. One of the primary uses for injectable nandrolone decanoate in medicine is the care of refractory anemia that is unresponsive to other forms of therapy. Nandrolone stimulates the kidneys to produce erythropoietin, which increases the bulk and volume of red blood cells.

• It’s not uncommon to see a bodybuilder use Nandrolone during the first half of his contest prep and then drop it the second half for steroids that are better suited to hardening, although he may leave in a small amount all the way to the end for therapeutic benefit.
• Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
• In a study by Clark and colleagues, the authors reported a case of a subject using several drugs, thus causing dilated cardiomyopathy 76.
• The development of nandrolone was an intermediate step in the eventual development of the 19-nortestosterone group of progestins, which are widely used in hormonal birth control.

To sum up, inflammatory cytokines, oxidative stress, protein synthesis alteration, and apoptosis are common mechanisms involved in AAS-related damage. Supra-physiologic doses of common AASs alter immune function by influencing the production of certain cytokines. In fact, the users of AASs have abnormal immunoglobulin (Ig) concentrations; the lowest levels of immunoglobulin G (IgG), immunoglobulin M (IgM) and immunoglobulin A (IgA), “significantly lower” than controls for IgA and IgM 129. Kanda and coauthors 130 showed that spontaneous IgM and IgG production in humans was inhibited by exposure to 1 nM testosterone, which is nearly a physiological dose, suggesting that high doses would potentially adversely affect the immune system. Some studies suggest that AASs are immune suppressive and depend on the type of AAS used and the dose and timing of administration.

However, nandrolone decanoate remains available from compounding pharmacies in the United States, for instance AnazaoHealth. It is only available from this particular pharmacy at a very high concentration of 200 mg/mL however, which although a potentially workable concentration for use in transmasculine people, is likely completely impractical for use in transfeminine people. Compounding pharmacies might be able to do custom concentrations upon request though. Testosterone is aromatized in small amounts into estradiol, and for this reason, testosterone has estrogenic activity. It may have positive effects on sexual desire in men as well (Wibowo & Wassersug, 2013).

The chronic effects of AAS abuse, aside from neuropsychiatric and behavioral effects, include a wide range of somatic consequences. Consequently, AASs may exert negative effects on reproductive, hepatic, musculoskeletal, endocrine, renal, immunologic, cardiovascular, cerebrovascular, and hematological systems 19,20,21,22. They can cause androgenic and masculinizing effects like oily skin, acne, seborrhea, facial/body hair growth, scalp hair loss, and voice deepening, among others.